Automatically tracking single cells in time-lapse sequences is crucial for many applications, such as understanding cell proliferation or cell migration, or evaluating the effects of therapeutics on cell behavior. SC-Track is a multi-object cell tracking algorithm that takes a stack of segmentation masks and produces single-cell tracks. The Mantle sc-track pipeline reads segmentation masks from your Mantle Database, performs cell tracking using SC-Track and recolors the masks to keep the cell identifiers consistent between images, and writes the recolored masks back to your Mantle Database.